Senator John McCain, the Vietnam war hero turned senator and presidential candidate, has died aged 81.
McCain died on Saturday surrounded by his family, according to a short statement released by his office.
He was diagnosed with an aggressive brain tumour in July 2017 and had been undergoing medical treatment.
His family announced McCain, who left Washington in December, had decided to stop treatment on Friday.
McCain’s daughter Meghan said the task of her lifetime would now be “to live up to his example, his expectations, and his love”.
“The days and years to come will not be the same without my dad – but they will be good days, filled with life and love, because of the example he lived for us,” she wrote in a statement shared on Twitter.
The six-term senator and 2008 Republican presidential nominee was diagnosed after doctors discovered his tumour during surgery to remove a blood clot from above his left eye last July.
The son and grandson of Navy admirals, Mr McCain was a fighter pilot during the Vietnam War. When his plane was shot down, he spent more than five years as a prisoner of war.
While in the custody of his captors, he suffered torture that left him with lasting disabilities.
Tributes began to pour in for McCain as soon as the news of his death was announced.
Donald Trump, whom McCain has strongly criticised, tweeted: “My deepest sympathies and respect go out to the family of Senator John McCain. Our hearts and prayers are with you!”
Sarah Palin, who was McCain’s running mate during his 2008 bid for president, said the world had lost “an American original”, sharing a picture of herself with the man she called her friend.
Tributes were also paid from the other side of the political spectrum.
Barack Obama, the Democrat who beat McCain to the presidency, said despite their differences, they shared “a fidelity to something higher – the ideals for which generations of Americans and immigrants alike have fought, marched and sacrificed.
“Few of us have been tested the way John once was, or required to show the kind of courage that he did,” Obama said. “But all of us can aspire to put the courage to put the greater good above our own.
“At John’s best, he showed us what that means.”
Former vice-president, long-time friend and political opponent Joe Biden said McCain’s “impact on America hasn’t ended”.
“John McCain’s life is proof that some truths are timeless,” he said in a statement. “Character. Courage. Integrity.
“A life lived embodying those truths casts a long, long shadow. John McCain will cast a long shadow.”